Report for the ESC First Contact Initiative
نویسندگان
چکیده
Thanks to this scholarship, I was able to visit the laboratory of Prof. Thomas Brand, Chair in Developmental Dynamics in the aforementioned host institute. This visit was divided in two parts. Initially, I visited the laboratory of Dr. Brand for three days in September 2015. During this visit, Dr. Brand showed me his laboratory and gave me an update on his line of research on the Popeye domain-containing (POPDC) proteins in determining the structure and function of cardiac and skeletal muscle. During this initial visit, I also had the opportunity to present my recent data on pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice in a talk organized at the Imperial Centre for Translational and Experimental Medicine (ICTEM). I also met with various researchers of the Section on Cardiovascular Function, which provided me with the opportunity to develop new contacts and to learn about the exciting research environment at this institution. After this initial contact, I planned together with Dr. Brand a second longer visit for a whole week that was finally set for October 2016. For this second visit, we planned several experiments, which focused on the role played by POPDC proteins in the control of sinoatrial node (SAN) pacemaking using the mouse POPDC1 null mutant as a model. My results constitute an interesting extension of the initial data obtained by Dr. Brand and will be likely used for a grant application to the Medical Research Council and form the basis for a joint publication. Moreover, thanks to these initial contacts, we are now establishing a long-term collaboration between my current laboratory (Dr. Mangoni, Institute for Functional Genomics in Montpellier) and Dr. Brand’s group, to merge my competence to study cardiac pacemaker activity and the wealth of knowledge of Dr. Brand in his functional studies of POPDC proteins.
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